黄薇
黄薇,女,1963年4月出生,博士/二级研究员。上海市生物医药技术研究院首席科学家,基因组与生物信息研究所所长,上海交通大学特聘教授,博士生导师。分别于1992年及2003年获得上海第二医科大学医学硕士学位和遗传学专业理学博士学位。现兼任上海市疾病与健康基因组学重点实验室主任,上海市基因测序与分析专业技术服务平台主任。历任国家人类基因组南方研究中心常务副主任、主任,上海市生物医药技术研究院副院长、党委委员。长期从事人类遗传多样性研究和疾病分子遗传学及基因组学研究,参与创建国家人类基因组南方研究中心、复旦大学附属肿瘤医院精准肿瘤中心等新型研发机构。近年来,利用多组学技术开展了肿瘤、自身免疫性疾病、心脑血管和代谢性疾病等多项临床转化研究,构建了多个高发肿瘤的“多组学”图谱和数据库,开发了多项肿瘤伴随诊断产品,为肿瘤分子分型及精准诊疗提供前沿技术支撑。现已主持国家及省部级各类科研项目30余项,发表学术论文200多篇,授权专利10余项。荣获国家自然科学奖二等奖、国家科技进步奖二等奖、教育部自然科学奖一等奖、二等奖、上海市科技进步奖一等奖等科技奖项30余项。曾获国家自然科学杰出青年基金、国务院政府特殊津贴,入选国家“百千万人才工程”、教育部跨世纪优秀人才、上海市优秀学科带头人和上海市领军人才等,荣获“全国有突出贡献中青年专家”、“全国优秀科技工作者”、“全国三八红旗手标兵”、上海市曙光学者、上海市“银蛇奖”等称号。近五年代表性学术论文(*通讯作者):1.Clinical sequencing defines the somatic and germline mutation landscapesof Chinese HER2-Low Breast Cancer. Bo-Yue Han, Chao Chen, Hong Luo, Cai-Jin Lin, Xiang-Chen Han,Javaria Nasir, Jin-Xiu Shi, Wei Huang, Zhi-Ming Shao, Hong Ling,Xin Hu. Cancer Letters2024, Apr5(4):673-690.2.Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities. Yi-Zhou Jiang, Ding Ma, Xi Jin, Yi Xiao, Ying Yu, Jinxiu Shi, Yi-Fan Zhou, Tong Fu, Cai-Jin Lin, Lei-Jie Dai, Cheng-Lin Liu, Shen Zhao, Guan-Hua Su, Wanwan Hou, Yaqing Liu, Qingwang Chen, Jingcheng Yang, Naixin Zhang, Wen-Juan Zhang, Wei Liu, Weigang Ge, Wen-Tao Yang, Chao You, Yajia Gu, Virginia Kaklamani, François Bertucci, Claire Verschraegen, Anneleen Daemen, Nakul M. Shah, Ting Wang, Tiannan Guo, Leming Shi, Charles M. Perou, Yuanting Zheng, Wei Huang*(并列通讯) Zhi-Ming Shao. Nature Cancer 2024, February 12https://www.nature.com/articles/s43018-024-00725-03.Comprehensive genomic profiling of Chinese breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities. Chao Chen, Cai-Jin Lin, Yu-Chen Pei, Ding Ma, Li Liao, SiYuan Li, Lei Fan, Gen-Hong Di, Song-Yang Wu, Xi-Yu Liu, Yun-Jin Wang, Qi Hong, Guo-Liang Zhang, Lin-Lin Xu, Bei-Bei Li, Wei Huang, Jin-Xiu Shi, Yi-Zhou Jiang, Xin Hu and Zhi-Ming Shao. Cell Discovery 2023, December 19 (9): 1254.Molecular classification of hormone receptor-positive HER2-negative breast cancer.Jin X, Zhou YF, Ma D, Zhao S, Lin CJ, Xiao Y, Fu T, Liu CL, Chen YY, Xiao WX, Liu YQ, Chen QW, Yu Y, Shi LM, Shi JX, Huang W, Robertson JFR, Jiang YZ, Shao ZM. Nat Genet. 2023 Oct. 55(10):1696-1708.5.Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy. Yang F, Xiao Y, Ding JH, Jin X, Ma D, Li DQ, Shi JX, Huang W, Wang YP, Jiang YZ, Shao ZM. Cell Metab. 2023 Jan 3;35(1):84-100.6.Genomic features of rapid versus late relapse in triple negative breast cancer. Zhang Y, Asad S, Weber Z, Tallman D, Nock W, Wyse M, Bey JF, Dean KL, Adams EJ, Stockard S, Singh J, Winer EP, Lin NU, Jiang YZ, Ma D, Wang P, Shi L, Huang W, Shao ZM, Cherian M, Lustberg MB, Ramaswamy B, Sardesai S, VanDeusen J, Williams N, Wesolowski R, Obeng-Gyasi S, Sizemore GM, Sizemore ST, Verschraegen C, Stover DG. BMC Cancer. 2021 May 18;21(1):568.7.Genome-wide association study of chronic spontaneous urticaria reveals genetic overlap with autoimmune diseases, not atopic diseases. Zhang, Liming; Qiu, Li; Wu, Jian; Qi, Yumeng; Gao, Xing-Hua; He, Chundi; Qi, Rui-Qun; Wang, Hexiao; Yao, Xu; Zhu, Hong; Li, Yuzhen; Hao, Siyu; Lu, Qianjin; Long, Hai; Lian, Shi; Zhu, Wei; Zhang, Haiping; Lai, Wei; Su, Xiangyang; Lu, Rongbiao; Guo, Zaipei; Li, Jingyi; li, mengmeng; Liu, Quanzhong; Wang, Huiping; He, Li; Nong, Xiang; Li, Fuqiu; Li, Yang; Yao, Chunli; Xu, Jinhua; Tang, Hui; Wang, Duoqin; Li, Zhenlu; Yu, Huiqian; Xiao, Shengxiang; An, Jingang; Pu, xiongming; Yu, Shirong; Zhang, Jianzhong ; Chen, Xue; Wang, Haifeng; Huang, Wei; Chen, Hong-Duo; Xiao, Ting. Journal of Investigative Dermatology.2021, Nov. 298.Identification of type 2 diabetes loci in 433,540 East Asian individuals.Spracklen CN, Horikoshi M, Kim YJ, Lin K, Bragg F, Moon S, Suzuki K, Tam CHT, Tabara Y, Kwak SH, Takeuchi F, Long J, Lim VJY, Chai JF, Chen CH, Nakatochi M, Yao J, Choi HS, Iyengar AK, Perrin HJ, Brotman SM, van de Bunt M, Gloyn AL, Below JE, Boehnke M, Bowden DW, Chambers JC, Mahajan A, McCarthy MI, Ng MCY, Petty LE, Zhang W, Morris AP, Adair LS, Akiyama M, Bian Z, Chan JCN, Chang LC, Chee ML, Chen YI, Chen YT, Chen Z, Chuang LM, Du S, Gordon-Larsen P, Gross M, Guo X, Guo Y, Han S, Howard AG, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Isono M, Jang HM, Jiang G, Jonas JB, Kamatani Y, Katsuya T, Kawaguchi T, Khor CC, Kohara K, Lee MS, Lee NR, Li L, Liu J, Luk AO, Lv J, Okada Y, Pereira MA, Sabanayagam C, Shi J, Shin DM, So WY, Takahashi A, Tomlinson B, Tsai FJ, van Dam RM, Xiang YB, Yamamoto K, Yamauchi T, Yoon K, Yu C, Yuan JM, Zhang L, Zheng W, Igase M, Cho YS, Rotter JI, Wang YX, Sheu WHH, Yokota M, Wu JY, Cheng CY, Wong TY, Shu XO, Kato N, Park KS, Tai ES, Matsuda F, Koh WP, Ma RCW, Maeda S, Millwood IY, Lee J, Kadowaki T, Walters RG, Kim BJ, Mohlke KL, Sim X. Nature.2020,May;582(7811):240-245.9.Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing. Guan-Tian Lang, Yi-Zhou Jiang, Jin-Xiu Shi, Fan Yang, Xiao-Guang Li, Yu-Chen Pei, Chen-Hui Zhang, Ding Ma, Yi Xiao, Peng-Chen Hu, Hai Wang, Yun-Song Yang, Lin-Wei Guo, Xun-Xi Lu, Meng-Zhu Xue, Peng Wang, A-Yong Cao, Hong Ling, Zhong-Hua Wang, Ke-Da Yu, Gen-Hong Di, Da-Qiang Li, Yun-Jin Wang, Ying Yu, Le-Ming Shi, Xin Hu, Wei Huang*(并列通讯) Zhi-Ming Shao.Nat Commun.2020 Nov 10; 11:5679.10.Multiple cancer susceptible genes sequencing in BRCA-negative breast cancer with high hereditary risk. Guan-Tian Lang, Jin-Xiu Shi, Liang Huang, A-Yong Cao, Chen-Hui Zhang, Chuan-Gui Song,Zhi-Gang Zhuang, Xin Hu, Wei Huang*(并列通讯), Zhi-Ming Shao, Ann Transl Med2020