李园园，女，1975年4月出生，博士/研究员，组学研究与应用研究组组长，复旦大学博士生导师。2003年获得中科院上海生命科学院生化细胞所博士学位。

学科领域为系统生物学，生物信息学，转化医学。主要从事以识别驱动因素及其信息传递交互机制为目的、融合跨尺度多模态数据与生物学规则的数据整合挖掘方法开发，肿瘤、自身免疫病等复杂系统疾病的关键调控因子及失调事件识别，机制解释性标志物及潜在药物靶标发现，疾病关联及其跨尺度机制研究等。

主持完成十余项国家及地方科研项目，包括国家重大研发计划、国家自然科学基金面上项目、上海市重大项目等。在PLoS Computational Biology、Bioinformatics、Advanced Science、EBioMedicine、Artificial Intelligence in Medicine、Molecular Systems Biology等SCI期刊发表论文83篇，其中通讯和第一作者论文54篇。获中国发明专利授权73项，软件著作权24项。

获上海市科技启明星、明治生命科学奖、华夏医学科技奖三等奖（第二完成人）、上海市科学技术奖二等奖（第二完成人）、中华预防医学会科学技术奖三等奖（第二完成人）等奖项，上海市三八红旗手、国务院政府特殊津贴专家等荣誉。

近五年代表性学术论文(*通讯作者)：

1. Yu Q, Li YY*, Chen Y*. scMalignantFinder distinguishes malignant cells in single-cell and spatial transcriptomics by leveraging cancer signatures. Communications Biology. 2025 Mar 27;8(1):504. doi: 10.1038/s42003-025-07942-y.

2. Yu J, Chen M, Sang Q, Feng H, Li F, Xu Z, Yu B, He C, Su L, Dai W, Yan C, Zhu Z, Xia J, Huang C, Li J, Chen Y*, Li YY*, Liu B*. Super-enhancer activates master transcription factor NR3C1 expression and promotes 5-FU resistance in gastric cancer. Advanced Science. 2025 Feb;12(7):e2409050. doi: 10.1002/advs.202409050.

3. Feng H, Yu J, Xu Z, Sang Q, Li F, Chen M, Chen Y, Yu B, Zhu N, Xia J, He C, Hou J, Wu X, Yan C, Zhu Z, Su L, Li J, Dai W*, Li YY*, Liu B*. SLC7A9 suppression increases chemosensitivity by inducing ferroptosis via the inhibition of cystine transport in gastric cancer. eBioMedicine 2024;109: 105375.

4. Wu Q, Huang Y, Kong X, Jia B, Lu X, Chen Y, Huang Z*, Li YY*, Dai W*. DBLiPro: A Database for Lipids and Proteins in Human Lipid Metabolism. Phenomics. 2023. https://doi.org/10.1007/s43657-023-00099-w

5. Sang Q, Dai W, Yu J, Chen Y, Fan Z, Liu JX, Li F, Li J, Wu X, Hou J, Yu B, Feng H, Zhu Z-G, Su L, Li YY*, Liu B*. Identification of prognostic gene expression signatures based on the tumor microenvironment characterization of gastric cancer. Frontiers in Immunology. 2022. 13:983632. doi: 10.3389/fimmu.2022.983632.

6. Yu B, Dai W, Pang L, Sang Q, Li F, Yu J, Feng H, Li J, Hou J, Yan C, Su L, Zhu Z, Li YY*, Liu B*. The dynamic alteration of transcriptional regulation by crucial TFs during tumorigenesis of gastric cancer. Molecular Medicine. 2022. 28, 41. https://doi.org/10.1186/s10020-022-00468-7

7. Li F, Li J, Yu J, Pan T, Yu B, Sang Q, Dai W, Hou J, Yan C, Zang M, Zhu Z, Su L, Li YY*, Liu B*. Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data. EBioMedicine. 2021 Jul 19;69:103436. doi: 10.1016/j.ebiom.2021.103436.

8. Li Q, Dai W, Liu J, Li YX*, Li YY*. DysRegSig: an R package for identifying gene dysregulations and building mechanistic signatures in cancer. Bioinformatics. 2021 Apr 20; 37(3): 429-430. doi: 10.1093/bioinformatics/btaa688.

9. Chen Y, Li H, Li YY*, Li Y*. Pan-cancer Analysis of Head-to-Head Gene Pairs in Terms of Transcriptional Activity, Co-expression and Regulation. Frontiers in Genetics. 2021 Jan 07. 11:560997. doi.org/10.3389/fgene.2020.560997