黄行许，男，1965年1月出生，研究员，基因编辑应用技术研究组组长，浙江大学求是特聘教授，浙江大学博士生导师。1998年获得南方医科大学医学博士学位。

长期从事基因编辑相关研究，在CRISPR基因编辑和检测领域做出了原创性工作。迄今已在Cell等发表论文 100 余篇，Google Scholar 被引 20000 余次；开发技术被包括美、英等42个国家的1200多家实验室使用（addgene最受欢迎载体“蓝色火焰奖”）；申请发明专利 30 余件，签约转化 10余件；研究工作获评Nature年度研究（2014）、Cell年度论文（2014）、MIT技术评论年度突破性技术（2014）、BioArt中国生命科学年度进展（2017）、Molecular Therapy年度论文（2018）、Science Bulletin年度论文（2021 & 2022）、中国科协第七届优秀科技论文（2022）等。Science、Nature、路透社、卫报、纽约时报等多次点评报道。黄行许博士是2018年第二届国际人类基因组编辑峰会特邀报告人，连续多年爱思唯尔高被引中国学者。

 近五年代表性学术论文(*通讯作者)：

1. Li, W., Jiang, X., Wang, W., Hou, L., Cai, R., Li, Y., Gu, Q., Chen, Q., Ma, P., Tang, J., Guo, M., Chuai, G.*, Huang, X.*, Zhang, J.*, Liu, Q*. (2024). Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models. Nature Communications, 15(1):10024.

2. Li, Z.#, Luo, L.#, Ju, X.#, Huang, S.#, Lei, L., Yu, Y., Liu, J., Zhang, P., Chi, T., Ma, P., Huang, C.*, Huang, X.*, Ding, Q.*, Zhang, Y*. (2024). Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis. The EMBO Journal, 43, 6444-6468.

3. Li, X.#, Zhang, G.#, Huang, S.#, Liu, Y., Tang, J., Zhong, M., Wang, X., Sun, W., Yao, Y., Ji, Q., Wang, X., Liu, J.*, Zhu, S.*, Huang, X.* (2023). Development of a versatile nuclease prime editor with upgraded precision. Nature Communications, 14(1):305.

4. Li, G., Zhang, Q., Liang, T., Huang, X. (2023). Precise insertions of large DNA fragments for cell and gene therapy. Science Bulletin, 68, 857-859.

5. Li, J.#, Lin, J.#, Huang, S.#, Li, M., Yu, W., Zhao, Y., Guo, J., Zhang, P., Huang, X.*, Qiao, Y. * (2022). Functional phosphoproteomics in cancer chemoresistance using CRISPR-mediated base editors. Advanced Science, 9(30):e2200717.

6. Huang, S.#, Zhang, Z.#, Tao, W.#, Liu, Y., Li, X., Wang, X., Harati, J., Wang, P.Y., Huang, X.*, Lin, C.P.* (2022). Broadening prime editing toolkits using Pol II-driven engineered pegRNA. Molecular Therapy, Jul 6:S1525-0016(22)00423-3.

7. Zhang, G.#, Liu, Y.#, Huang, S.#, Qu, S., Cheng, D., Yao, Y., Ji, Q., Wang, X.*, Huang, X.*, Liu, J.* (2022). Enhancement of prime editing via xrRNA motif-joined pegRNA. Nature Communications, 13(1):1856.

8. Wang, Y.#, Zhang, G.#, Meng, Q.#, Huang, S., Guo, P., Leng, Q., Sun, L., Liu, G.*, Huang, X.*, Liu, J.* (2022). Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors. Nature Communications, 13(1):1454.

9. Dang, L., Zhou, X., Zhong, X., Yu, W., Huang, S., Liu, H., Chen, Y., Zhang, W., Yuan, L., Li, G. (2022). Correction of the pathogenic mutation in TGM1 gene by adenine base editing in mutant embryos. Molecular Therapy, 30, 175-183.

10. Li, Z.#, Luo, L.#, Yu, W., Li, P., Ou, D., Liu, J., Ma, H., Sun, Q., Liang, A., Huang, C., Chi, T., Huang, X.*, Zhang, Y.* (2022). PPARγ phase separates with RXRα at PPREs to regulate target gene expression. Cell Discovery, 8, 1-15.

11. Li, G., Li, X., Zhuang, S., Wang, L., Zhu, Y., Chen, Y., Sun, W., Wu, Z., Zhou, Z., Chen, J., et al. (2022). Gene editing and its applications in biomedicine. Science China Life Sciences, 65, 660-700.

12. Lu, Z.#, He, S.#, Jiang, J.#, Zhuang, L.#, Wang, Y., Yang, G., Jiang, X., Nie, Y., Fu, J., Zhang, X., Lu, Y., Bian, X., Chang, H.C., Xiong, Z., Huang, X.*, Liu, Z.*, Sun, Q.* (2022). Base-edited Cynomolgus Monkeys mimic core symptoms of STXBP1 encephalopathy. Molecular Therapy, S1525-0016(22)00157-5.

13. Li, X., Huang, X. (2022). Towards precise large genomic fragment deletion. Trends in Genetics, 38(3):214-215.

14. Liu, Y., Chen, Y., Dang, L., Liu, Y., Huang, S., Wu, S., Ma, P., Jiang, H., Li, Y., Pan, Y., Wei, Y., Ma, X., Liu, M., Ji, Q., Chi, T., Huang, X.*, Wang, X.*, Zhou, F.* (2021). EasyCatch, a convenient, sensitive and specific CRISPR detection system for cancer gene mutations. Molecular Cancer, 20(1):157.

15. Liu, Y.#, Yang, G.#, Huang, S.#, Li, X., Wang, X., Li, G., Chi, T., Chen, Y., Huang, X.*, Wang, X.* (2021). Enhancing prime editing by Csy4-mediated processing of pegRNA. Cell Research, 31(10):1134-1136.

16. Li, J.#, Yu, W.#, Huang, S.#, Wu, S., Li, L., Zhou, J., Cao, Y., Huang, X.*, Qiao, Y.* (2021). Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity. Nature Communications, 12(1):2287.

17. Luo, L. #, Li, Z. #, Zhao, T. #, Ju, X. #, Ma, P., Jin, B., Zhou, Y., He, S., Huang, J., Xu, X., Zou, Y., Li, P., Liang, A., Liu, J., Chi, T., Huang, X.*, Ding, Q.*, Jin, Z.*, Huang, C.*, Zhang, Y.* (2021). SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production. Science Bulletin, 66, 1194-1204.

18. Liu, Y.#, Zhou, C.#, Huang, S.#, Dang, L.#, Wei, Y., He, J., Zhou, Y., Mao, S., Tao, W., Zhang, Y., Yang, H.*, Huang, X.*, Chi, T.* (2020). A Cas-embedding strategy for minimizing off-target effects of DNA base editors. Nature Communications, 11(1):6073.

19. Ma, P.#, Meng, Q.#, Sun, B.#, Zhao, B.#, Dang, L., Zhong, M., Liu, S., Xu, H., Mei, H., Liu, J., Chi, T., Yang, G., Liu, M.*, Huang, X.*, Wang, X.* (2020). MeCas12a, a highly sensitive and specific system for COVID-19 detection. Advanced Science, 7(20):2001300.

20. Li, J.#, Liu, Z.#, Huang, S.#, Wang, X., Li, G., Xu, Y., Yu, W., Chen, S., Zhang, Y., Ma, H., Ke, Z., Chen, J.*, Sun, Q.*, Huang, X.* (2019). Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome. Cell Research, 29(2):174-176.

21. Yang, G.#, Zhou, C.#, Wang, R.#, Huang, S., Wei, Y., Yang, X., Liu, Y., Li, J., Lu, Z., Ying, W., Li, X., Jing, N., Huang, X.*, Yang, H.*, Qiao, Y.* (2019). Base-editing-mediated R17H substitution in histone H3 reveals methylation-dependent regulation of Yap signaling and early mouse embryo development. Cell Reports, 26(2):302-312.e4.