潘鸿捷，男，1983年3月15日出生，博士学位。上海市生物医药技术研究院 副研究员。复旦大学药理学院药理学专业硕士生导师，上海理工大学健康科学与工程学院生物医学工程硕士生导师，中共党员。2014年获华东师范大学生物医学理学博士学位，同年进入上海市计划生育科学研究所工作，任助理研究员。2019年晋升副研究员。2022年4月任上海市生物医药技术研究院生殖健康研究所副研究员。主持和参与国家及省部委级项目多项，横向到位经费70万。

l 2020年度“上海计生所优秀共产党员”等荣誉。

l 中国药理学会生殖药理专业委员会委员。

Dr. Hongjie Pan

Gender: Male

Date of Birth: March 15, 1983

Current Position:

Associate Researcher, Shanghai Institute of Biomedical Technology

 Education & Professional Experience:

2009–2013 Ph.D. in Biomedical Sciences, East China Normal University
Advisor: Prof. Mingyao Liu

2006–2009 M.S. in Aquaculture, Shanghai Ocean University
Advisor: Prof. Shengli Cai

2002–2006 B.S. in Biological Science, Zhejiang Ocean University

 Research Projects:

1、Epigenetic Regulation of Gamete & Related Disorders

Gamete (sperm and oocyte) development is central to life propagation, with quality directly determining reproductive success and offspring health. Epigenetic regulation has been identified as a critical determinant of gametogenesis, closely linked to reproductive disorders and transgenerational effects. Our team investigates the epigenetic mechanisms governing gamete development, focusing on the synergistic roles of DNA methylation/hydroxymethylation, RNA modifications (e.g., m⁶A), and protein post-translational modifications (ubiquitination, sulfhydrylation, etc.). We further explore how environmental factors (e.g., endocrine disruptors, oxidative stress) epigenetically compromise gamete quality. By integrating cutting-edge epigenomics with clinical needs, we aim to advance reproductive medicine from empirical treatments to precision interventions.

2、Microenvironment of Gamete Development & Associated Pathologies

Gamete maturation relies on a tightly coordinated microenvironment involving germ cell-somatic cell crosstalk, metabolic homeostasis, hormonal signaling, and immune regulation. In ovarian follicles, microenvironmental dysregulation can lead to gametogenesis failure, accelerated follicular atresia, and diminished ovarian reserve, contributing to infertility and premature ovarian failure (POF). The rising incidence of POF (ovarian dysfunction before age 40) severely impacts female fertility and long-term health, yet its etiology remains elusive. Our work deciphers the dynamic regulatory networks of the gamete niche, emphasizing: Granulosa cell-oocyte communication; Metabolic reprogramming (e.g., oxidative stress and energy metabolism); Immune microenvironment (e.g., macrophage polarization); Angiogenesis and their collective impact on oocyte quality and ovarian reserve. Through clinical cohorts and gene-edited models, we elucidate POF pathogenesis and pioneer microenvironment-targeted strategies.